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But fellow defender James Tomkins could return after a thigh injury while midfielders James McArthur and Joe Ledley are also back in contention.
Striker Loic Remy has resumed training but needs a couple of reserve matches before he is considered.
Connor Wickham, Bakary Sako, Pape Souare and Steve Mandanda remain long-term absentees.
Arsenal are likely to be without Theo Walcott for the clash.
The forward missed the Boxing Day win over West Brom with a minor calf problem and is not expected to recover in time to face the Eagles.
Kieran Gibbs (knee) is definitely out while Shkodran Mustafi is fit and available following a hamstring injury.
Danny Welbeck’s return from a long-term knee problem is progressing well.
Arsenal provisional squad: Cech, Ospina, Bellerin, Jenkinson, Holding, Gabriel, Mertesacker, Koscielny, Mustafi, Monreal, Elneny, Coquelin, Xhaka, Oxlade-Chamberlain, Ozil, Reine-Adelaide, Walcott, Iwobi, Sanchez, Giroud, Welbeck.
Crystal Palace provisional squad: Hennessey, Speroni, Ward, Dann, Tomkins, Kelly, Fryers, Lee, Ledley, Phillips, Winter, Husin, McArthur, Townsend, Boateng, Zaha, Cabaye, Mutch, Puncheon, Benteke, Campbell, Flamini.